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KMID : 1123920070210030771
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Korean Journal of Oriental Physiology and Pathology
2007 Volume.21 No. 3 p.771 ~ p.775
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Protective Effect of Licorice Water Extract against Cadmium-induced Nephro-toxicity in Rats
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Lee Jong-Rok
Kim Sang-Chan
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Abstract
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Licorice has been used for cure of injuries and for detoxification in East Asia. This study investigated the protective effect of licorice water extract against cadmium (CdCl, Cd)-induced nephro-toxicity in rats. To induce acute toxicity, Cd (4 mg/kg body weight) was dissolved in normal saline and then, intravenously (i.v.) injected to animals. In experiments, animals were orally administrated with vehicle or licorice water extract (50-100 mg/kg) for 3 days, exposed to a single injection of Cd after 24 h the last licorice/vehicle treatment. Licorice protected kidney injuries by Cd treatment. The number of glomeruli showing vasodilatation and thickening of Bowman’s capsule was dose-dependently decreased by licorice. These results suggest that licorice might be a potent preventive protector against Cd-induced nephro-toxicity in rats.
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KEYWORD
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licorice, cadmium, rat, kidney
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